Genome complexity: Z-DNA a new layer of complexity (Introduction)
Still not fully understood but it represents left-handed DNA coils appearing in the normally right-handed turns with va special relationship to coding RNA:
https://www.omagdigital.com/publication/?m=21896&i=661897&p=46
Comment: Unfortunately I cannot copy the article but it indicates that some process flips DNA back and forth extremely quickly and this modifies the way RNA is edited and instructed in expressing genes. it also can be modified by methyl groups to give epigenetic changes. Another layer of complexity is uncovered, and I assume more to come. Only design fits.