One paragraph of what has been presented needed a correction: - "In the 1990s Schuster and his colleagues devised a computer program that could predict the simplest features of an RNA's shape (its secondary structure, which is how parts of the chain stick to other parts by pairing-up of bases) from its sequence. For an RNA of 100 bases, there are around 10^23 possible shapes of this sort. But what was remarkable was the way these shapes and their sequences were related. - Note the change in the number from 1023 to exponential 10^23. It becomes an enormous number and yet the author thinks that gives the evolutionary search for useful molecules an easier path! Coordinated patterns do simply, but the numbers are still huge.