This article covers the 'start' and 'stop' mechanisms of the inflammation reaction to injury or infection. To show an example lets use blood clotting. No start and you bleed to death; no stop and you clot to death. With inflammation you can die from overwhelming infection or lack of healing of a wound if there is no 'start'. If there is no 'stop' you can die of autoimmune diseases like Lupus (many organs affected), glomerulonephritis (Kidneys destroyed), Rheumatic fever (heart damage, heart failure and death), etc.-http://www.sott.net/articles/show/235026-Vagus-Nerve-Neurotransmitter-Regulated-Immunity