A very thorough review by James Shapiro of his contenton that mutations do not drive evolution as much as natural genetic engineering: gene transfer, DNA implanted by viruses and amoeba. Symbiosis with cells adding mitochondria and chloroplasts. Transpositions and retrotranspositions and hosts of oher methods. Regulatory RNA's, etc. etc. etc. The actual list is huge.-http://shapiro.bsd.uchicago.edu/Shapiro.2013.RNABIOL0220.pdf