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Message:

> Special new abilities found:
> 
> https://www.sciencedaily.com/releases/2024/02/240208142446.htm
> 
> "Researchers from The Australian National University (ANU) have discovered a previously unknown ability of a group of immune system cells, known as Atypical B cells (ABCs), to fight infectious diseases such as malaria.
> 
> ***
> 
> "'Although ABCs are known to contribute to chronic inflammatory diseases and autoimmunity, we've discovered a previously unknown ability of these cells to fight disease. In this sense, ABCs are like a double-edged sword.
> 
> "'Contrary to past belief, ABCs are not junk cells; they are more important than we thought.
> '
> "'Our research found that ABCs are also instrumental in developing T follicular helper cells. These helper cells generate powerful antibodies that help the body fight malaria parasites.
> 
> "'Antibodies can block parasites in the blood as they travel from the site of the infectious mosquito bite to the liver, where the infection is first established."
> 
> ***
> 
> "Using gene-editing technology on mice, the ANU researchers discovered a gene called Zeb2 is crucial to the production of ABCs.
> 
> "'We found that manipulating the Zeb2 gene disrupted the creation of ABCs in the immune system," study co-author Professor Ian Cockburn, from The ANU John Curtin School of Medical Research, said.
> 
> "'Importantly, we found that mice without the Zeb2 gene were unable to control malaria infection.
> 
> "'Therefore, the findings show that ABCs play a crucial role in fighting malaria infections."
> 
> ***
> 
> "'ABCs also appear in large numbers in many autoimmune diseases, including lupus, which can be life-threating in severe cases," Professor Cockburn said."
> 
> Comment: The immune system is very complex and leads to therapeutic manipulation possibilities.