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> Found in mice, a newly found coding base thought to be epigenetically originated:-http://www.washingtonpost.com/entertainment/tv/unreal-and-another-period-from-female-creators-sharp-jabs-at-reality/2015/06/22/c7944832-16cc-11e5-9ddc-e3353542100c_story.html?wpisrc=nl_headlines&wpmm=1-If true this opens up a much more Lamarckian view of innovation.- "An epigenetic mark known as 5-formylcytosine (5fC) may be more than a transitory state that helps regulate gene expression. According to a study published yesterday (June 22) in Nature Chemical Biology, 5fC is stable in the mouse genome and may represent a fifth nucleotide in the DNA alphabet.-&#147;&apos;It had been thought this modification was solely a short-lived intermediate, but the fact that we&apos;ve demonstrated it can be stable in living tissue shows that it could regulate gene expression and potentially signal other events in cells,&#148; coauthor Shankar Balasubramanian of the Cancer Research UK Cambridge Institute said in a press release.-"While the function of the modified base&#151;essentially a methylated cytosine with added oxygen&#151;remains unclear, its position within the genome points to a role in gene expression. &#147;This modification to DNA is found in very specific positions in the genome&#151;the places which regulate genes,&#148; lead author Martin Bachman, who conducted the research while at the University of Cambridge, said in the release. &#147;In addition, it&apos;s been found in every tissue in the body&#151;albeit in very low levels.&#148; High-resolution mass spectrometry revealed 5fC to be most common in the mouse brain, but even there it was present at only 10 parts per million or less.-"But when the researchers enriched cultures of mouse cells or mice&apos;s diets with stable isotopes of carbon and hydrogen, they found no uptake into 5fC bases, suggesting the modification is stable.-&#147;&apos;If 5fC is present in the DNA of all tissues, it is probably there for a reason,&#148; added Balasubramanian. &#147;This will alter the thinking of people in the study of development and the role that these modifications may play in the development of certain diseases.&apos;&#148;