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> When hey have to migrate upstream to reproduce, this enzyme helps the circulatory system:
> 
> https://phys.org/news/2019-06-salmon-major-athletic-boost-enzyme.html
> 
> "Salmon species, known for undertaking arduous upstream migrations, appear to owe a good deal of their athletic ability to the presence of a single enzyme. 
> 
> "New research indicates that plasma-accessible carbonic anhydrase (paCA)—an enzyme anchored to the walls of salmons' blood vessels—helps reduce how hard their hearts have to work during exercise by up to 27 percent.
> 
> "'Salmon species get one shot at reproduction, and we know cardiovascular performance can be a limiting factor during migration," says zoologist Till Harter, who led the study while a researcher at the University of British Columbia (UBC).
> 
> "'It appears paCA plays a key role in enhancing the animal's ability to extract oxygen from their blood, making salmon great aerobic athletes and giving them a much-needed edge during migration."
> 
> "The researchers also found the paCA enzyme kicked in when the fish were exposed to low water oxygen levels—hypoxia—and helped the salmon recover faster from exercise.
> 
> "'Like hypoxia, increases in water temperature are also thought to limit aerobic performance," says UBC researcher Colin Brauner, senior author on the paper.
> 
> "'If elevated temperature recruits paCA like hypoxia does, there may be levels at which fish can acclimate and be better prepared to deal with elevated temperatures associated with climate change."
> 
> "'Like hypoxia, increases in water temperature are also thought to limit aerobic performance," says UBC researcher Colin Brauner, senior author on the paper.
> 
> "'If elevated temperature recruits paCA like hypoxia does, there may be levels at which fish can acclimate and be better prepared to deal with elevated temperatures associated with climate change.'"
> 
> Comment: A reminder. Enzymes are giant complex  molecules which facilitate speed in protein reactions. How did chance evolution find this specific molecule? Since salmon  have such a complex migratory reproduction system, this system and enzyme must have been designed.