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> What is described in this article about glutathione is probably another feedback loop in the immune system:
> 
> https://cosmosmagazine.com/biology/detox-molecule-triggers-t-cell-immune-response?utm_source=Today+in+Cosmos+Magazine&utm_campaign=0e9767a51b-RSS_EMAIL&utm_medium=email&utm_term=0_5f4ec2b124-0e9767a51b-180078025
> 
> "An antioxidant previously thought to be simply one of the body’s garbage collectors has been found to double as a critical switch for the immune system.
> 
> "Glutathione, a molecule known to remove harmful metabolic byproducts such as free radicals, also functions to power up the immune system’s frontline bug-killers – a type of white blood cell known as T-cells.
> 
> ***
> 
> "Understanding the complex factors that affect the activity of T-cells is a key target for immunology research around the globe. The cells, like any type of predator, represent a mixed blessing.
> 
> "In the best of circumstances they attack and defeat invading pathogens. In the worst, they attack the body itself.
> 
> “'If its innate defences are overactive,” says Brenner, “then they turn against the body. This is what happens in auto-immune diseases like multiple sclerosis or arthritis. 
> 
> “'However if the defences are too weak, then infections cannot be handled, or body cells can proliferate uncontrolled and grow to form tumours, which can become life threatening.” 
> 
> "Glutathione – which is catalysed by a gene known as Gclc – has previously been identified as playing an important role in tackling the byproducts of T-cell activity.
> 
> "When the body is free from infection, T-cells exist in a state of low-energy readiness, rather like a squad of commandos during peacetime. When pathogens invade, however, the T-cells spring into action, revving up their metabolisms as they do so.
> 
> "[b]This increase in activity results in the production of potentially toxic waste – primarily free radicals and reactive oxygen species – and it is these that glutathione moves in to clean up. [/b] (my bold)
> 
> "Brenner’s team, however, identified a second role for the molecules. The research reveals that glutathione functions to trigger the T-cell activity in the first place, and is thus an important switch for the regulation of the immune system.
> 
> "The discovery provides a valuable insight into the development of auto-immune diseases, which are linked to malfunctions in T-cell activity."
> 
> Comment: Over a lifetime T cells build up a library of defenses in their DNA. They must have a signal chemical to activate them and having tied to cleanup after the battle is over makes perfect sense as a biological feedback loop control. It is a system that protects against oxidative damage from infection fighting. It must be developed intact, a saltation, to avoid damage secondary to immunity.