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> Recent research shows a complex mechanism of flowering control:
> 
> http://www.ibs.re.kr/cop/bbs/BBSMSTR_000000000738/selectBoardArticle.do?nttId=14075
> 
> "Epigenetic regulation is one of the major mechanisms to control flowering time. It regulates gene expression through chemical modifications of DNA and its interacting proteins, but without changing the DNA sequence. If you think of the DNA contained in each cell as a big book that contains all the information, these chemical modifications can be thought as bookmarks that tell the cell which pages to read and which to skip over time. A particular type of chemical modification called acetylation, occurring on DNA bounded proteins (histones), can be promoted or removed by specific proteins. Arabidopsis has at least 18 proteins that remove these chemical modifications and are referred to as histone deacetylases (HDACs). Which are the targets of HDACs, how they coordinate with each other and how they interact with other proteins is still unclear. This study discovered the proteins that interact to one of these chemical modifications that controls the time of flowering.
> 
> "IBS researchers concentrated on the ninth HDAC, known as HDA9. This protein is known to regulate several biological processes, such as flowering time, seed dormancy and stress responses. The team found that plants lacking this protein bloomed earlier and have enlarged fruits, indicating that the regulation of the stem cells activity was compromised. The same happens when POWERDRESS (PWR) (a protein already studied by the same research team for its regulation of floral stem cells), or both HDA9 and PWR are missing.
> 
> "The scientists discovered that PWR and HDA9 form a protein complex that removes the chemical modifications from a protein bound to DNA called histone 3. In the same way as removing a bookmark from the "DNA book" indicates that you do not need to read the pages next to the bookmark, removing this chemical modification reduces the production of AGL19, a protein that causes early flowering. In this way, plants maintain normal flowering time.
> 
> "'PWR, HDA9 and AGL19 regulate flowering time. A plant with reduced PWR and HDA9 has increased AGL19 levels and flowers earlier," explains Kim. "The opposite situation, that is the overexpression of PWR and HDA9, has not been tested yet."
> 
> "The next challenge for the team is to study other chemical modifications (or "bookmarks") on plants' histones and clarify how these different chemical modifications together regulate flowering."
> 
> Comment: The article does not mention the size of the deacetylases, but the name implies they are enzymes, and therefore giant molecules of a particular shape. How did plant evolution develop just the right molecule of this type to control flowering. It certainly suggests design or saltation. Note this is a different epigenetic modification, not methylation but acetylation.